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Country Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe That year 59% of California voters approved CIRM, which had been placed on the ballot as a response to restrictions imposed by then-President George W. Bush’s administration on the use of federal funding for studies of stem cells derived from human embryos. At the time, the National Institutes of Health (NIH) could only fund work on a small number of preexisting human embryonic cell lines. (Former President Barack Obama’s administration later lifted those restrictions.)CIRM initially expected to focus on human embryonic stem cells, but later expanded its remit to more specialized adult stem cells such as those that form blood or the increasingly popular induced pluripotent stem (iPS) cells, created by reprogramming adult cells to an embryolike state. CIRM’s money led to the creation of major stem cell centers in California and lured several biotech companies to set up shop in the state. Although CIRM supported infrastructure, basic research, and training early on, in the past 3 years it has poured most of its remaining $759 million into clinical trials—a total of 55 of which are ongoing or completed to date—as the agency faced pressure to produce the medical treatments its supporters were initially promised.In a memo to its board released on 20 June, CIRM said it had received applications totaling $88 million in its latest funding call but had only $33 million left to distribute. The agency announced the next day that it was taking no new grant applications as of 28 June, aside from a sickle cell disease program jointly funded with NIH. “There is no money available for new projects,” CIRM communications director Kevin McCormack wrote in a 1 July blog post.Some researchers who explore the basic science of stem cells had already been looking for other funding sources as CIRM began to emphasize clinical work and their support wound down. But others, especially those planning clinical trials, will be hit hard. “It’s going to be a huge impact on my lab and many others if they end,” says April Pyle of UC Los Angeles (UCLA), whose 11-person group works on using muscle stem cells to treat muscular dystrophy. Her last CIRM grant ends in March 2020 and although she also has some NIH funding, it does not support the animal testing and other studies needed to move her work toward a clinical trial.Future clinical work will face “at best significant delays, and many projects to identify new therapies will stop” if the agency doesn’t continue, says gene therapy researcher Donald Kohn, who heads several such trials at UCLA.CIRM’s efforts to raise $200 million in bridge funding from private sources have been unsuccessful to date. Now, CIRM boosters are looking to a $5.5 billion bond initiative that real estate developer Robert Klein, who led the original push to create the agency, hopes to add to the November 2020 ballot.If approved, “We would hope there would be very little gap” in funding, McCormack says. But if the voters reject the initiative, he expects CIRM’s staff to dwindle and the agency to fold by about 2023. By Jocelyn KaiserJul. 9, 2019 , 3:35 PM Stem cell scientists in California who have benefited from a $3 billion state research agency created in 2004, at the height of federal limits on working with cells from human embryos, have long known that it would eventually run out of money. That reality set in last month, when the California Institute for Regenerative Medicine (CIRM) in Oakland announced it is no longer taking grant applications.Ongoing payments for approved projects continue, but scientists are already tightening their belts for a funding gap. They are also contemplating the end of a boom in stem cell research in the state. California’s voters may be asked to renew CIRM with another bond initiative next year, “but there’s no guarantee,” says Arnold Kriegstein, who heads a stem cell center at the University of California (UC), San Francisco, and has received CIRM funding in the past.Longtime CIRM grantee Jeanne Loring, who retired in June from the Scripps Research Institute in San Diego, California, and runs a biotech startup to advance one of her projects, says the agency has made the state the “center of the stem cell universe. It would be tragic to unravel [that infrastructure] now. But the funding in 2004 was so dependent on the politics and interest at the time, and I don’t know if those circumstances can be replicated.” Click to view the privacy policy. Required fields are indicated by an asterisk (*)center_img One legacy of California’s $3 billion stem cell research agency is the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at the University of Southern California in Los Angeles.  Email California’s stem cell research fund dries up ZUMA Press, Inc./Alamy Stock Photo last_img


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